The school districts listed below represent the biggest schools in the United States by enrollment. The 2011 AS&U 100 — a compilation of the nation's 100 largest school districts — also provides the following data:
| Rank | School District | State | Enrollment (2009-10) |
| 1 | New York City | NY | 1,038,741 |
| 2 | Los Angeles Unified | CA | 670,746 |
| 3 | Chicago | IL | 407,157 |
| 4 | Miami-Dade County | FL | 345,804 |
| 5 | Clark County | NV | 307,059 |
| 6 | Broward County | FL | 256,137 |
| 7 | Houston | TX | 202,773 |
| 8 | Hillsborough County | FL | 193,265 |
| 9 | Hawaii | HI | 180,196 |
| 10 | Orange County | FL | 173,259 |
| 11 | Palm Beach | FL | 172,897 |
| 12 | Fairfax County | VA | 171,956 |
| 13 | Philadelphia | PA | 165,694 |
| 14 | Gwinnett County | GA | 159,296 |
| 15 | Dallas | TX | 157,111 |
| 16 | Montgomery County | MD | 141,722 |
| 17 | Wake County | NC | 140,558 |
| 18 | Charlotte-Mecklenburg County | NC | 136,969 |
| 19 | San Diego Unified | CA | 131,417 |
| 20 | Prince George's County | MD | 127,039 |
| 21 | Duval County | FL | 122,586 |
| 22 | Memphis | TN | 109,300 |
| 23 | Cobb County | GA | 107,245 |
| 24 | Pinellas County | FL | 105,238 |
| 25 | Cypress-Fairbanks | TX | 104,231 |
| 26 | Baltimore County | MD | 103,324 |
| 27 | DeKalb County | GA | 99,406 |
| 28 | Jefferson County | KY | 98,808 |
| 29 | Albuquerque | NM | 96,572 |
| 30 | Polk County | FL | 94,530 |
| 31 | Northside | TX | 92,335 |
| 32 | Detroit | MI | 90,499 |
| 33 | Fulton County | GA | 90,399 |
| 34 | Long Beach Unified | CA | 86,283 |
| 35 | Jefferson County | CO | 86,282 |
| 36 | Austin | TX | 84,676 |
| 37 | Baltimore City | MD | 82,866 |
| 38 | Milwaukee | WI | 82,096 |
| 39 | Lee County | FL | 80,484 |
| 40 | Fort Worth | TX | 80,209 |
| 41 | Denver | CO | 77,267 |
| 42 | Prince William County | VA | 76,861 |
| 43 | Fresno Unified | CA | 75,468 |
| 44 | Nashville-Davidson County | TN | 75,080 |
| 45 | Anne Arundel County | MD | 74,776 |
| 46 | Guilford County | NC | 72,758 |
| 47 | Brevard County | FL | 72,412 |
| 48 | Virginia Beach | VA | 71,182 |
| 49 | Greenville | SC | 70,969 |
| 50 | Granite | UT | 70,595 |
| 51 | Davis | UT | 69,689 |
| 52 | Fort Bend | TX | 69,374 |
| 53 | Mesa Unified | AZ | 67,471 |
| 54 | Pasco County | FL | 67,147 |
| 55 | Alpine | UT | 65,918 |
| 56 | North East | TX | 65,498 |
| 57 | Washoe County | NV | 64,838 |
| 58 | Seminole County | FL | 64,457 |
| 59 | Arlington | TX | 63,487 |
| 60 | El Paso | TX | 63,378 |
| 61 | Aldine | TX | 62,792 |
| 62 | Mobile County | AL | 62,767 |
| 63 | Elk Grove Unified | CA | 62,483 |
| 64 | Volusia County | FL | 62,306 |
| 65 | Loudoun County | VA | 60,003 |
| 66 | Douglas County | CO | 59,932 |
| 67 | Chesterfield County | VA | 59,509 |
| 68 | Katy | TX | 59,078 |
| 69 | Garland | TX | 57,861 |
| 70 | Santa Ana Unified | CA | 56,937 |
| 71 | Knox County | TN | 56,758 |
| 72 | Boston | MA | 55,371 |
| 73 | Tucson Unified | AZ | 55,369 |
| 74 | San Antonio | TX | 55,327 |
| 75 | San Francisco Unified | CA | 55,140 |
| 76 | Plano | TX | 54,939 |
| 77 | San Bernardino Unified | CA | 53,837 |
| 78 | Capistrano Unified | CA | 53,381 |
| 79 | Cumberland County | NC | 53,035 |
| 80 | Columbus | OH | 52,810 |
| 81 | Forsyth County | NC | 52,795 |
| 82 | Pasadena | TX | 52,303 |
| 83 | Osceola County | FL | 52,139 |
| 84 | Corona-Norco Unified | CA | 52,052 |
| 85 | Cherry Creek | CO | 51,786 |
| 86 | Lewisville | TX | 50,840 |
| 87 | Howard County | MD | 50,641 |
| 88 | Clayton County | GA | 50,204 |
| 89 | Conroe | TX | 49,629 |
| 90 | Anchorage | AK | 49,592 |
| 91 | Henrico County | VA | 49,407 |
| 92 | Brownsville | TX | 49,121 |
| 93 | Atlanta | GA | 48,909 |
| 94 | Jordan | UT | 48,853 |
| 95 | Omaha | NE | 48,692 |
| 96 | Cleveland | OH | 48,392 |
| 97 | Wichita | KS | 48,324 |
| 98 | Shelby County | TN | 48,211 |
| 99 | Garden Grove Unified | CA | 47,950 |
| 100 | Sacramento City Unified | CA | 47,890 |
| 101 | San Juan Unified | CA | 47,327 |
| 102 | Seattle | WA | 46,522 |
| 103 | Oakland Unified | CA | 46,099 |
| 104 | Portland | OR | 45,748 |
| 105 | Alief | TX | 45,553 |
| 106 | Klein | TX | 44,824 |
| 107 | Jefferson Parish | LA | 44,713 |
| 108 | Ysleta | TX | 44,620 |
| 109 | Washington, D.C. | DC | 43,866 |
| 110 | Charleston | SC | 43,063 |
| 111 | Round Rock | TX | 43,008 |
| 112 | Manatee County | FL | 42,939 |
| 113 | Collier County | FL | 42,714 |
| 114 | Riverside Unified | CA | 42,696 |
| 115 | Oklahoma City | OK | 42,549 |
| 116 | East Baton Rouge Parish | LA | 42,307 |
| 117 | Sweetwater Union High | CA | 42,209 |
| 118 | Marion County | FL | 42,005 |
| 119 | Adams 12 Five Star | CO | 41,949 |
| 120 | Hamilton County | TN | 41,832 |
| 121 | Caddo Parish | LA | 41,757 |
| 122 | Tulsa | OK | 41,493 |
| 123 | Elgin Unit-46 | IL | 41,446 |
| 124 | Socorro | TX | 41,357 |
| 125 | Sarasota County | FL | 41,281 |
| 126 | Lake County | FL | 41,050 |
| 127 | Fontana Unified | CA | 41,004 |
| 128 | Henry County | GA | 40,951 |
| 129 | United | TX | 40,885 |
| 130 | Escambia County | FL | 40,613 |
| 131 | Salem-Keizer | OR | 40,259 |
| 132 | Frederick County | MD | 40,159 |
| 133 | Anoka-Hennepin | MN | 39,904 |
| 134 | Chesapeake | VA | 39,883 |
| 135 | Killeen | TX | 39,603 |
| 136 | Newark | NJ | 39,443 |
| 137 | Union County | NC | 39,395 |
| 138 | St. Lucie County | FL | 39,013 |
| 139 | Gilbert Unified | AZ | 38,800 |
| 140 | Harford County | MD | 38,636 |
| 141 | St. Paul | MN | 38,531 |
| 142 | Cherokee County | GA | 38,293 |
| 143 | Corpus Christi | TX | 38,196 |
| 144 | Chandler Unified | AZ | 38,147 |
| 145 | Stockton Unified | CA | 38,141 |
| 146 | Beaverton | OR | 38,120 |
| 147 | Clovis Unified | CA | 38,004 |
| 148 | Kern Union High | CA | 37,928 |
| 149 | Horry | SC | 37,790 |
| 150 | Rutherford County | TN | 37,679 |
| 151 | Clear Creek | TX | 37,611 |
| 152 | Peoria Unified | AZ | 37,500 |
| 153 | Mesquite | TX | 37,272 |
| 154 | Fayette County | KY | 36,988 |
| 155 | Adams-Arapahoe | CO | 36,967 |
| 156 | Moreno Valley Unified | CA | 36,822 |
| 157 | Deer Valley Unified | AZ | 36,241 |
| 158 | Jefferson County | AL | 36,058 |
| 159 | St. Tammany Parish | LA | 36,021 |
| 160 | Clay County | FL | 35,956 |
| 161 | Spring | TX | 35,350 |
| 162 | Minneapolis | MN | 35,076 |
| 163 | Humble | TX | 34,923 |
| 164 | Lincoln | NE | 34,915 |
| 165 | Richardson | TX | 34,843 |
| 166 | Chatham County | GA | 34,668 |
| 167 | Buffalo | NY | 34,526 |
| 168 | Mount Diablo | CA | 34,316 |
| 169 | Meridian | ID | 34,233 |
| 170 | Forsyth County | GA | 34,208 |
| 171 | Norfolk | VA | 34,011 |
| 172 | Frisco | TX | 33,973 |
| 173 | Poway | CA | 33,797 |
| 174 | Irving | TX | 33,679 |
| 175 | Canyons | UT | 33,678 |
| 176 | Cincinnati | OH | 33,449 |
| 177 | Indianapolis | IN | 33,372 |
| 178 | Anaheim Union High | CA | 33,187 |
| 179 | Paradise Valley Unified | AZ | 33,146 |
| 180 | Calcasieu Parish | LA | 32,905 |
| 181 | Des Moines | IA | 32,749 |
| 182 | Montebello Unified | CA | 32,739 |
| 183 | Leon County | FL | 32,733 |
| 184 | Rochester | NY | 32,516 |
| 185 | Spring Branch | TX | 32,502 |
| 186 | Durham | NC | 32,470 |
| 187 | Muscogee County | GA | 32,458 |
| 188 | Richmond County | GA | 32,449 |
| 189 | San Jose Unified | CA | 32,423 |
| 190 | Saddleback Valley Unified | CA | 32,387 |
| 191 | Gaston County | NC | 32,351 |
| 192 | Fremont Unified | CA | 32,304 |
| 193 | Edinburg | TX | 32,011 |
| 194 | Chino Valley Unified | CA | 31,992 |
| 195 | Johnston County | NC | 31,960 |
| 196 | Amarillo | TX | 31,890 |
| 197 | Montgomery County | AL | 31,764 |
| 198 | Mansfield | TX | 31,662 |
| 199 | Keller | TX | 31,569 |
| 200 | Fort Wayne | IN | 31,549 |