| 1 | University of Phoenix-Online Campus | 224,880 | 165,373 | 35.98% |
| 2 | Miami Dade College | 54,094 | 51,329 | 5.39% |
| 3 | Ohio State University-Main Campus | 52,568 | 51,818 | 1.45% |
| 4 | University of Florida | 51,725 | 50,912 | 1.60% |
| 5 | Arizona State University at the Tempe Campus | 51,481 | 51,234 | 0.48% |
| 6 | University of Minnesota-Twin Cities | 50,883 | 50,402 | 0.95% |
| 7 | The University of Texas at Austin | 50,170 | 49,697 | 0.95% |
| 8 | University of Central Florida | 48,398 | 46,646 | 3.76% |
| 9 | Texas A & M University | 46,542 | 45,380 | 2.56% |
| 10 | City College of San Francisco | 46,411 | 44,392 | 4.55% |
| 11 | Michigan State University | 46,045 | 45,520 | 1.15% |
| 12 | University of South Florida | 44,870 | 43,636 | 2.83% |
| 13 | Houston Community College System | 43,518 | 42,526 | 2.33% |
| 14 | Pennsylvania State University-Main Campus | 43,252 | 42,914 | 0.79% |
| 15 | University of Illinois at Urbana-Champaign | 42,326 | 42,738 | -0.96% |
| 16 | New York University | 41,783 | 40,870 | 2.23% |
| 17 | University of Wisconsin-Madison | 41,563 | 41,028 | 1.30% |
| 18 | Northern Virginia Community College | 41,266 | 38,166 | 8.12% |
| 19 | University of Michigan-Ann Arbor | 41,042 | 40,025 | 2.54% |
| 20 | Florida State University | 40,555 | 39,973 | 1.46% |
| 21 | Purdue University-Main Campus | 40,534 | 40,609 | -0.18% |
| 22 | University of Washington-Seattle Campus | 40,218 | 39,524 | 1.76% |
| 23 | North Harris Montgomery Community College District | 39,756 | 40,846 | -2.67% |
| 24 | Indiana University-Bloomington | 38,990 | 38,247 | 1.94% |
| 25 | Florida International University | 38,182 | 37,997 | 0.49% |
| 26 | Tarrant County College District | 37,948 | 34,777 | 9.12% |
| 27 | College of Southern Nevada | 37,758 | 35,414 | 6.62% |
| 28 | University of California-Los Angeles | 37,476 | 36,611 | 2.36% |
| 29 | University of Arizona | 37,217 | 36,805 | 1.12% |
| 30 | California State University-Fullerton | 37,130 | 35,921 | 3.37% |
| 31 | California State University-Long Beach | 36,868 | 35,574 | 3.64% |
| 32 | University of Maryland-College Park | 36,014 | 35,102 | 2.60% |
| 33 | Strayer University | 35,754 | 30,654 | 16.64% |
| 34 | San Diego State University | 35,695 | 33,441 | 6.74% |
| 35 | California State University-Northridge | 35,446 | 34,560 | 2.56% |
| 36 | University of California-Berkeley | 34,940 | 33,920 | 3.01% |
| 37 | Excelsior College | 34,894 | 30,665 | 13.79% |
| 38 | Rutgers University-New Brunswick | 34,804 | 34,392 | 1.20% |
| 39 | University of North Texas | 34,710 | 33,395 | 3.94% |
| 40 | Temple University | 34,696 | 33,865 | 2.45% |
| 41 | University of Houston | 34,663 | 34,334 | 0.96% |
| 42 | Brigham Young University | 34,174 | 34,185 | -0.03% |
| 43 | University of Georgia | 33,831 | 33,959 | -0.38% |
| 44 | American River College | 33,821 | 31,908 | 6.00% |
| 45 | Santa Ana College | 33,514 | 33,203 | 0.94% |
| 46 | Austin Community College District | 33,508 | 33,039 | 1.42% |
| 47 | University of Southern California | 33,408 | 33,389 | 0.06% |
| 48 | Pima Community College | 32,982 | 32,532 | 1.38% |
| 49 | Valencia Community College | 32,870 | 30,245 | 8.68% |
| 50 | Kaplan University | 32,734 | 25,168 | 30.06% |
