The higher-education institutions listed below represent the biggest colleges and universities in the United States by enrollment. The 2009 AS&U Higher Education 20 — a compilation of the nation's 20 largest higher education institutions — also provides the following data:
| Rank | Institution | Enrollment (2007-08) |
|---|
| 1 | University of Phoenix-Online Campus | 224,880 |
| 2 | Miami Dade College | 54,094 |
| 3 | Ohio State University-Main Campus | 52,568 |
| 4 | University of Florida | 51,725 |
| 5 | Arizona State University at the Tempe Campus | 51,481 |
| 6 | University of Minnesota-Twin Cities | 50,883 |
| 7 | The University of Texas at Austin | 50,170 |
| 8 | University of Central Florida | 48,398 |
| 9 | Texas A & M University | 46,542 |
| 10 | City College of San Francisco | 46,411 |
| 11 | Michigan State University | 46,045 |
| 12 | University of South Florida | 44,870 |
| 13 | Houston Community College System | 43,518 |
| 14 | Pennsylvania State University-Main Campus | 43,252 |
| 15 | University of Illinois at Urbana-Champaign | 42,326 |
| 16 | New York University | 41,783 |
| 17 | University of Wisconsin-Madison | 41,563 |
| 18 | Northern Virginia Community College | 41,266 |
| 19 | University of Michigan-Ann Arbor | 41,042 |
| 20 | Florida State University | 40,555 |
| 21 | Purdue University-Main Campus | 40,534 |
| 22 | University of Washington-Seattle Campus | 40,218 |
| 23 | North Harris Montgomery Community College District | 39,756 |
| 24 | Indiana University-Bloomington | 38,990 |
| 25 | Florida International University | 38,182 |
| 26 | Tarrant County College District | 37,948 |
| 27 | College of Southern Nevada | 37,758 |
| 28 | University of California-Los Angeles | 37,476 |
| 29 | University of Arizona | 37,217 |
| 30 | California State University-Fullerton | 37,130 |
| 31 | California State University-Long Beach | 36,868 |
| 32 | University of Maryland-College Park | 36,014 |
| 33 | Strayer University | 35,754 |
| 34 | San Diego State University | 35,695 |
| 35 | California State University-Northridge | 35,446 |
| 36 | University of California-Berkeley | 34,940 |
| 37 | Excelsior College | 34,894 |
| 38 | Rutgers University-New Brunswick | 34,804 |
| 39 | University of North Texas | 34,710 |
| 40 | Temple University | 34,696 |
| 41 | University of Houston | 34,663 |
| 42 | Brigham Young University | 34,174 |
| 43 | University of Georgia | 33,831 |
| 44 | American River College | 33,821 |
| 45 | Santa Ana College | 33,514 |
| 46 | Austin Community College District | 33,508 |
| 47 | University of Southern California | 33,408 |
| 48 | Pima Community College | 32,982 |
| 49 | Valencia Community College | 32,870 |
| 50 | Kaplan University | 32,734 |
